The University is located in Orenburg City which is 1,478 kilometers (918 mi) southeast from Moscow. OSMU is very close to the border with Kazakhstan. Nowadays, there are over 550 scientific and staff members working with this University.

Orenburg State Medical University is considered to the best University in Russia. The faculty provides the students with the field of General Medicine. Around 200 specialists pass out every year from this University who serve the patients all across the globe. During the training program, there are around 54 subjects for the students. There are around 47 departments and 300 professors and associate professors and doctors. The students get the chance to learn from the basics of the human body to the entire functioning of the body. The students of OSMU are provided with hands-on training in the hospital campus itself for the treatment of the patients. Within the syllabus, research work is included so that students can enhance their learning skills.